在英语中，表示“不管你心情如何”的常用表达有：

No matter how you feel.
Regardless of how you feel.
It doesn't matter how you feel.

这些表达都表示，不论某人的心情如何，都会有一定的事情要做或者某种情况要应对。

例句：

No matter how you feel, you have to go to work tomorrow. (不管你心情如何，明天还是得去上班。)
Regardless of how you feel, you need to eat something. (不管你心情如何，你还是需要吃点东西。)
It doesn't matter how you feel, we have to finish this project by tomorrow. (不管你心情如何，我们还是得在明天之前完成这个项目。)