在英语中，表示“他不要她了”可以用一下几种表达方式：

He no longer wants her.
He has lost interest in her.
He has moved on from her.
He has broken up with her.
He has ended the relationship with her.

这些表达方式均表示“他不再对她有兴趣或不再与她在一起”的意思。

例句：

He no longer wants her - 他不再要她了。
He has lost interest in her - 他对她失去了兴趣。
He has moved on from her - 他已经不再和她在一起了。
He has broken up with her - 他和她分手了。
He has ended the relationship with her - 他和她的关系已结束。